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Notably, animal models have demonstrated that transferring dysbiotic microbiota from CFS/ME patients to germ-free mice can induce fatigue-like behaviors, supporting a causal role for the microbiome in disease pathogenesis ( 3.5.4 Gut microbiota-based therapeutic interventions 3.5.4.1 Probiotics Given these findings, probiotic supplementation, particularly with strains of Lactobacillus and Bifidobacterium , has shown potential to restore microbial balance, enhance SCFA production, and reduce inflammation in CFS/ME patients (Skjevling et al., 2024)

Mortier PB, Martinot VL, Anastassov Y, Kulik JF, Duhamel A, Pellerin PN

Cilostazol significantly reduced ovarian tissue oxidative stress markers in rats treated with CP via decreasing MDA levels and increasing SOD and GSH levels compared to control rats (Abdel-Aziz et al

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